Posted by jerrympls on June 8, 2004, at 20:26:19
In reply to The motivation issue, posted by blanding on June 8, 2004, at 20:02:53
>
> Hi Jerry,
>
> I've got the same problem, and I've been on a combo of the TCA trimipramine (50 mg) and the SSRI sertraline (75 mg) since about a year.
>
> These two meds decisevely keep me from falling into severe troughs of depressions, yet I have no "drive" or motivation to clean myself or apt.
> Every second or third day I take either alprazolam (1 mg) or diazepam (10-20 mg), both benzodiazepines, in order to get the necessary "kick" to get these basic chores done.
>
> Since I'm afraid of getting addicted, I don't use them daily, so for the long run this is merely a mediocre type of solution.
>
> You write about Seroquel muting your dopamine. Does this med enhance dopamine levels or inhibit dopamine's action?
>Hello!
From what I know about Seroquel - it effects MANY dopamine receptors and areas within the brain. The theory - as I understand it - is that those with schizophrenia have overactive dopamine in certain areas a sub-receptor types in the brain, so anti-psychotics like Seroquel kinda dampen things. My diagnosis is Major Depression recurrent w/ GAD - no schizophrenia. But, from what I've read, anti-psychotics used in depressed people can make them numb, apathetic, etc. because of the dampening effects of the dopamine/reward system. I could be wrong - perhaps CHEMIST could shed some light.
Anyway...ugh...I just wished I could get things together!
Jerry ;-)
poster:jerrympls
thread:354883
URL: http://www.dr-bob.org/babble/20040608/msgs/354901.html