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Re: does anyone rerember Miltown? » 1980Monroe

Posted by chemist on May 8, 2004, at 1:26:15

In reply to does anyone rerember Miltown?, posted by 1980Monroe on May 7, 2004, at 22:58:19

> I read it was some old antianxiety used in the late 50's before the benzodiazepines.
>
> My grandpa still takes it, i had insomnia when we were camping on a hiking trail. I was too paranoid i would i would get attack by something, didnt know, a bear, moose, big foot,anything. Finally he just said take a miltown, and shut up. Had never heard of it before, but it worked. I heard it has barbiturate-like actions, exept not as toxic.
>
> asked him how long he's taken it, siad off and on from way back in the 50's. Apparently he told me everyone took it at one time, it was a blockbuster like prozac. Then it just burned out after Valium came in the 60's.
>
> How does anyone one know why it didnt stay around?

hello there, chemist here....miltown is quite an effective anxiolytic, and it is my guess that the side-effects/potential for addiction (the latter being questionable, from what i have read) were the reason why benzodiazepines came to the scene, which were regarded as superior to miltown. it is a carbamate derivative, as is the insecticide carbaryl, and to the best of my knowledge, exerts anxiolytic effects via a different pathway than inhibition of GABA reuptake and/or increased GABA production. just my opinion, but i would take as needed and look for something with a less-homologous molecular profile than an insecticide, if your anxiety perseveres. and i do not think there was a conspiracy among drug companies for the ``almighty $$$'' on this one, it appears to simply be a case of a safer class of drugs with less hepatic impairment having come on the market....all the best, chemist


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