Posted by SLS on April 25, 2004, at 8:31:51
In reply to Re: MAOI causes hypotension - What's the mechanism?, posted by djmmm on April 25, 2004, at 8:06:06
> > I get the impression that the mechanisms by which MAOIs produce hypotension are poorly understood. One piece that I found stated that it definitely was not due to NE alpha-1 antagonism. The following is an excerpt from:
> > http://www.acnp.org/g4/GN401000046/CH046.html> I too came across that link, however I found several more indicating that it is the antagonism of adrenergic receptors..so who knows...but I do know that severe hypotension (associated with overdose) is often treated with Levophed (norepinephrine) because this med stimulates alpha and beta adrenergic receptors.
It never ceases to amaze me how little research has been performed toward elucidating the mysteries of a class of drugs that have been around for over 40 years.
Thanks for taking the time.
:-)
- Scott
poster:SLS
thread:339531
URL: http://www.dr-bob.org/babble/20040423/msgs/339804.html