Posted by Ame Sans Vie on April 8, 2004, at 19:59:40
In reply to Re: Tramadol: headache at first or always? » Ame Sans Vie, posted by spoc on April 8, 2004, at 17:48:47
> Wow, thanks a ton! I was indeed hoping to smoke you personally out amongst any responses! And might I add that I love your PB name. So melodic. Does it translate into anything? : )
I'm glad to hear you got something out of my posts. :-)
Ame Sans Vie = Lifeless Soul (French); hardly an appropriate moniker considering my current happy frame of mind, but it's what everyone knows me by so I guess it stays. <shrug>
> Is the available testing only for the purpose of discovering how a person metabolizes drugs in the class you mentioned? Or could a deficiency discovered there also translate to problems with other types of drugs -- even psy drugs (so that I could know not to bother with them)?
Well, there's really no way of saying that a particular drug isn't worth trying until you've tried it; we all vary too much individually. But there are a few things to keep in mind; here's a list of the more common drugs metabolized by CYPIID6 -- their activity may be increased (in most cases) or decreased (as for the opioids) if you are deficient:
codeine, dextromethorphan, dihydrocodeine, hydrocodone, oxycodone, tramadol, ethylmorphine, venlafaxine (Effexor), MCPP (a metabolite of nefazodone [Serzone]), trazodone (Desyrel), maprotiline (Ludiomil), metoprolol, alprenolol, bufuralol, labetalol, penbutolol, propranolol (Inderal), timolol, paroxetine (Paxil), citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), norfluoxetine (a Prozac metabolite), N-desmethyl-sertraline (a metabolite of sertraline [Zoloft]), meth/amphetamine (Adderall, Dexedrine, DextroStat, Desoxyn), benztropine (Cogentin), amitriptyline (Elavil), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), N-desmethyl-clomipramine (metabolite of Anafranil), nortriptyline (Aventyl/Pamelor), diphenhydramine (Benadryl), loratadine (Claritin), omeprazole (Prilosec), perphenazine (Trilafon), risperidone (Risperdal), chlorpromazine (Thorazine), clozapine (Clozaril), haloperidol (Haldol), thioridazine (Mellaril), ondansetron (Zofran), papaverine, atomoxetine (Strattera), yohimbine
There are also drugs which can inhibit or induce the activity of certain enzymes; induction of CYPIID6 could possibly allow you to better tolerate certain medications, but unfortunately it seems that this particular enzyme is uniquely uninduceable! So the main things to watch out for are the *inhibitors*, which will slow down further a process that may already be defunct in your body:
Prozac, Paxil, and quinidine are *very* potent inhibitors of IID6. Taking them along with certain meds metabolized by IID6 could alter the effect drastically.
Elavil, Celexa, Lexapro, Luvox, Remeron, Edronax, Risperdal, Zoloft, and Effexor are less potent inhibitors, but may cause undesired effects nonetheless.
> Are there other things that this deficiency can state about a person; such as that irrespective of any ingested drugs, their bodies usually need the supplements x, y, and z? Or that this is actually their only real problem in life, and they can now proceed to move mountains, win friends and influence people on a large scale? (Ok, maybe I'm kidding about the last part). : )
lol, well that's a bit outside my area of patient expertise. I'm not really sure what (if anything) can be done about inefficient CYPIID6 metabolizers other than avoiding or approaching with caution the drugs which mess around with it.
Just let me know if you need anything else! :-)
~Michael
poster:Ame Sans Vie
thread:334061
URL: http://www.dr-bob.org/babble/20040407/msgs/334288.html