Posted by Iansf on March 14, 2004, at 19:09:02
In reply to Re: Mirapex for SSRI SD, posted by King Vultan on March 14, 2004, at 11:04:45
> If you look at sexual function as being divided into three phases, desire, arousal, and orgasm, SSRIs can have direct negative effects in both the desire and orgasm phases. The mechanism is slightly different in each case, however. The problems in the desire phase are thought to be caused by stimulation of serotonin 2A receptors in the brain, with reduction of dopamine in the brain's pleasure centers. The orgasm problems are thought to be due to stimulation of serotonin 2A receptors in the spinal cord, with inhibitory effects on the reflexes involved in orgasm. In either case, a drug that blockades serotonin 2A receptors such as trazodone or Remeron should theoretically correct the problem, but a pro-dopaminergic agent such as Wellbutrin or Mirapex would appear to mainly be useful only for those problems that are primarily libido related.
Trazodone is effective for SSRI caused sexual dysfunction? I've never heard this. Do you happen to know if the effect would last till the next day? Since trazodone puts most people to sleep, the sexual benefits wouldn't be worth much unless they were still in effect after you wake up.
poster:Iansf
thread:323962
URL: http://www.dr-bob.org/babble/20040313/msgs/324400.html