Posted by scott-d-o on January 29, 2004, at 14:44:47
In reply to Re: doxepin, remeron, whatever.. thread is off-top » scott-d-o, posted by Sad Panda on January 29, 2004, at 7:44:35
>
> Scott, I am familiar with the first abstract, it says
> 1. Mirtazapine is a presynaptic alpha-2 antagonist
> 2. Mirtazapine is a postsynaptic serotonergic 5-HT2 and 5-HT3 antagonist
> 3. Mirtazapine has a weak affinity for 5-HT1 receptors
> 4. Mirtazapine is a very weak muscarinic anticholinergic antagonist
> 5. Mirtazapine is a histamine (H1) antagonist
>
> It DOES NOT say weak or very weak histamine anatgonist.
>
> The second abstract is incorrect. Mianserin is a potent anti-histamine too as it is the older brother of Mirtazapine.
>
> I will post some more about it when I find it again on the web.
>
> Cheers,
> Panda.
>you're prob right about that abstract, like most abstracts, it is poorly worded.;-) I think doxepin has only slightly higher affinity than mirtazapine for h1 (I think mirtazapine binds with a pKi value around 9 and doxepin has a pKi around 10), but doxepin is not as selective and has much stronger h2 antagonism, so I think overall it is much more antihistaminic.. but then again I'm already sick of talking about it.. i guess a lot of it depends on where u get your data from also.
scott
poster:scott-d-o
thread:306217
URL: http://www.dr-bob.org/babble/20040127/msgs/306919.html