Posted by Ame Sans Vie on January 15, 2004, at 7:11:30
In reply to Grapefruit interactions-trazodone and citalopram, posted by Patient on January 14, 2004, at 16:44:41
Thanks for posting this! Some of us here are well aware of the grapefruit juice interactions with many, many drugs via inhibition of metabolism through the CYP450 3A4 pathway, but it's important to have reminders for those who do not know and don't make a habit of reading through the PB archives.
Though I've known about this interaction for several years (ever since I read "Do not take with grapefruit or grapefruit juice" on the side of a bottle of Xanax and decided to read up on it), it's pretty shocking that only *one* doctor of the two dozen or so I've seen over the past few years ever mentioned this interaction. However, he actually brought it up as a way to increase the effects of the 3mg/day Xanax I was taking at the time so that he wouldn't have to write a larger prescription. I hate grapefruit juice, so he prescribed Serzone instead, which very potently inhibits 3A4 and approximately doubled the effects of the Xanax and increased duration by 150%.
poster:Ame Sans Vie
thread:300793
URL: http://www.dr-bob.org/babble/20040114/msgs/301034.html