Posted by scott-d-o on January 8, 2004, at 1:08:38
In reply to Amisulpride Substitutes?, posted by Epiphany on January 8, 2004, at 0:23:29
> I started taking Amisulpride at 25mg a while ago after reading here about peoples positive responses to it for dysthymia+anhedonia. Well It really worked for me! For the first time in a long time I could enjoy little things again and feel connected to the world and people. Unfortunately though, I can no longer obtain it from the source I used to and now I have no other options. Anyone here that benefited from Amisulpride find help with something similar? It
> is the only drug that has ever worked for me. Please help!Here's a quote I pulled from this link: http://paddy42.tripod.com/Culturally_Ecclectic/merk_mood.htm
"The antipsychotic amisulpride, a dopamine agonist unavailable in the USA, in low doses (25 to 50 mg/day) has been reported to be effective. The antipsychotic trifluoperazine 1 mg/day is roughly equivalent and may be used in refractory cases of severe dysthymia but only when its benefits outweigh the risk of tardive dyskinesia from long-term use."
However, I have no personal experience with the antipsychotic mentioned and I can't be too confident of the information presented on this site since it refers to amisulpride as a dopamine agonist, when it is actually a dopamine antagonist. The antipsychotic mentioned also binds at D1-type (D1,D5) type receptors, where as sulpiride/amisulpride bind only at D2-type (D2,D3,D4) receptors.
poster:scott-d-o
thread:297940
URL: http://www.dr-bob.org/babble/20040105/msgs/297945.html