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Re: Zyprexa Abilify cancel each other?

Posted by SLS on December 14, 2003, at 17:12:17

In reply to Re: Zyprexa Abilify cancel each other?, posted by hawkeye on December 14, 2003, at 16:52:29

> Zyprexa acts as a full agonist at the D2 recptor. Therefore, it would seem that any advantages offered by Abilify's partial agonist mechanism would be drowned by Zyprexa's full agonist mechanism.

I imagine you meant to say "Zyprexa's full antagonist mechanism".

I had thought about that, but Abilify binds to the D2 receptor much more tightly than Zyprexa, so I don't think Zyprexa would knock Abilify loose from postsynaptic receptors.


- Scott

 

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poster:SLS thread:289704
URL: http://www.dr-bob.org/babble/20031213/msgs/289774.html