Re: topamax-how does it work

Posted by Shawn. T. on October 7, 2003, at 23:26:46

In reply to topamax-how does it work, posted by loolot on October 7, 2003, at 19:19:38

Topamax (topiramate) is an inhibitor of carbonic anhydrase (CA) isoenzymes; the drug is a more potent inhibitor of CA II and CA IV than of CA I, CA III, and CA VI. This action is responsible for topiramate's effects on GABA-A receptors such as the reduction of depolarizing responses mediated by the receptors (see the second reference for more details). Topiramate has also been shown to inhibit both the fast and persistent components of sodium currents in neocortical cells. In addition, the drug may inhibit L-type voltage-gated calcium channels. Finally, topiramate may inhibit inward currents evoked by some subtypes of kainate and AMPA glutamate receptors.
I'm not aware of any published articles that show that topiramate possesses dopaminergic actions.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10768298&dopt=Abstract
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11804617&dopt=Abstract
http://jpet.aspetjournals.org/cgi/content/full/288/3/960
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10768293&dopt=Abstract
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10768300&dopt=Abstract
Shawn

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topamax-how does it work loolot 10/7/03
Re: topamax-how does it work Shawn. T. 10/7/03
Re: thanks for the info...i just started it today (nm) » Shawn. T. Sabina 10/7/03

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