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Re: topamax-how does it work

Posted by Shawn. T. on October 7, 2003, at 23:26:46

In reply to topamax-how does it work, posted by loolot on October 7, 2003, at 19:19:38

Topamax (topiramate) is an inhibitor of carbonic anhydrase (CA) isoenzymes; the drug is a more potent inhibitor of CA II and CA IV than of CA I, CA III, and CA VI. This action is responsible for topiramate's effects on GABA-A receptors such as the reduction of depolarizing responses mediated by the receptors (see the second reference for more details). Topiramate has also been shown to inhibit both the fast and persistent components of sodium currents in neocortical cells. In addition, the drug may inhibit L-type voltage-gated calcium channels. Finally, topiramate may inhibit inward currents evoked by some subtypes of kainate and AMPA glutamate receptors.

I'm not aware of any published articles that show that topiramate possesses dopaminergic actions.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10768298&dopt=Abstract

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11804617&dopt=Abstract

http://jpet.aspetjournals.org/cgi/content/full/288/3/960

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10768293&dopt=Abstract

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10768300&dopt=Abstract

Shawn


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poster:Shawn. T. thread:266516
URL: http://www.dr-bob.org/babble/20031004/msgs/266602.html