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btnd: DXO for NMDA antagonism?

Posted by Ame Sans Vie on August 31, 2003, at 20:30:25

I was reading through the DXM FAQ on Erowid, and came across the following:

"Dextrorphan is a metabolite of DXM (i.e., the body converts DXM to dextrorphan). The conversion from DXM to DXO occurs via removal of the methyl group at position 6, a process called "O-demethylation". DXO is very similar chemically to DXM, and reacts with the same receptors in the body, but with a very different spectrum. Whereas DXM is strongest at the PCP2 and sigma receptors, DXO primarily targets the NMDA receptor (see Section 10)."

I've been supplementing myself with 30mg of Delsym twice daily for a few days now with a definite, yet subtle, increase of the potency of my tramadol in particular -- not at all surprising considering its use by opioid addicts to potentiate their drugs. But I think switching to DXO sounds more reasonable. I'm sure I could get it through a research chemical supplier that I occasionally use to order legal psychedelic phenethylamines and tryptamines... what do you think of this? Thanks!


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poster:Ame Sans Vie thread:255990
URL: http://www.dr-bob.org/babble/20030828/msgs/255990.html