Posted by DSCH on August 11, 2003, at 3:59:53
In tracking down information on future drugs aimed at ADD/ADHD, I came across Perceptin, which was being persued by Gliatech until it seems trouble with class-action litigation and the FDA over their post-surgical adhesion control gel ADCON-L sank the company.
Perceptin, "GT-2331", is a selective H3 receptor antagonist. (For a peak at the molecule, go here... http://www.albmolecular.com/features/tekreps/vol03/no25/ and scroll down a bit).
Bring up histamine, and I immediately have a lot of things to say about it, having gone through extensive allergy shot therapy as a kid. I commonly took the OTC anti-histamine Chlortrimeton which is chlorpheniramine, an H1 antagonist. I have felt seriously awful the few times I have taken Benedryl, which is diphenhydramine and another H1 antagonist. Well, my allergy attacks tapered off with time, though I still have them on occasion usually late at night starting with diarrhea before the bronchial constriction and nasal congestion kick in (food allergy?). More mucking about with Google scared up a number of sites proclaming "Allergic Toxema", "Allergic Tension Fatigue Syndrome", and (shudder) "Chronic Fatigue Immune Dysfunction Syndrome".
Could all this histamine-related activity from allergy attacks, therapy, and medication from when I was young resulted in damage or imbalance that is now reflected with symptoms that lately crop up as hypersomniac depression/ADD?
Is it possible I need more synaptic histamine rather than dopamine, norepinepherine, or serotonin? If so, how do I go about getting it?
Your thoughts, please!
poster:DSCH
thread:249973
URL: http://www.dr-bob.org/babble/20030807/msgs/249973.html