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Re: re: dividing granules,Rx note

Posted by noa on July 20, 2003, at 9:50:52

In reply to Re: re: dividing granules,Rx note » mercedes, posted by zinya on July 20, 2003, at 1:56:25

Yes, it isn't the outside gelcap that determines the time release, but....

If you look carefully, the granules are of different sizes. I once broke one open and saw the varying sizes of the granules. I believe that the reason for this is that it is the coating on each granule that determines the time release--ie, the thicker the coating, the longer it takes for the active medication to be released.

So, that would mean that you should be evenly distributing granules of different sizes into each of the portions you are making, which makes it a very involved task.

So--this is quite different than the applesauce thing. If you break open the capsule and take all of the granules at once (eg, in applesauce), it is not a problem. But if you divide them up, unless you carefully divide the different size granules (I am not sure how many different sizes there are), you are not getting the proper time release action, and you might be getting very uneven levels from day to day. I think this is the reason for the warning.


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