Re: Effexor metabolite in Phase III testing

Posted by djmmm on July 10, 2003, at 15:23:28

In reply to Re: Effexor metabolite in Phase III testing, posted by stjames on July 10, 2003, at 14:45:28

> > I heard about this, it's desvenlafaxine (O-desmethylvenlafaxine) it is slightly more potent than the parent drug, and it's half life is about 10 hours compared to venlafaxine's 4 hour half-life.
>
> This would be a very useful "least patentable difference". I wonder the effect of taking just one active vs many actives (from the parent) &
> if there is any synergy between the actives
I think they singled out the O-desmethylvenlafaxine metabolite because the N-desmethyl and N,O,-didesmethyl metabolites are less active (not as potent) as the parent drug

Thread

Effexor metabolite in Phase III testing jrbecker 7/10/03
Re: Effexor metabolite in Phase III testing djmmm 7/10/03
Re: Effexor metabolite in Phase III testing stjames 7/10/03
Re: Effexor metabolite in Phase III testing djmmm 7/10/03
Re: Effexor metabolite in Phase III testing SLS 7/10/03
Re: Effexor metabolite in Phase III testing djmmm 7/12/03

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