Posted by Ritch on June 17, 2003, at 9:53:26
In reply to Re: BPD, GRK, and dopamine, posted by jrbecker on June 16, 2003, at 12:44:54
> There's no doubt that the genetic underpinnings of bipolar disorder are multidimensional, so the news of this discovery should be taken with a grain of salt. However, I do think the GRK link does have some clout to it. G-protein coupled receptor kinase (GRK-3) is largely responsible for modulation of dopamine activity. GRK-3 dysfunction might partially explain why cycling causes such drastic mood changes, and furthermore, why many bipolars are much more sensitive to dopaminergic meds than their unipolar counterparts. Other kinases have been theorized to play a similar role in BPD, including glycogen-synthase kinase-3 (GSK-3beta) -- also implicated in Alzheimer's and diabetes; as well as protein kinase C (PKC).
>
> By the way, John Kelsoe's BPD genetic research is very highly respected in the field, so it's not like this info's coming out of left field. THe GRK-3 research has been building for a while now...
>
> http://www.psycheducation.org/depression/fitness.htm
>
>
Hey, I never noticed that on the site before. Thanks. A therapist that I was seeing in the '80's showed me something that I thought was interesting-except it was focused on the psycho-social elements of why it (bipolar disorder) exists. Basically, the gist of it was that people with bipolar perform a *social role* as inventors, story-tellers, preachers/shamans. I remember a picture of an aboriginal campfire scene on the front of the document with the priest (or shaman) raising his hands and telling a story-while everyone was carefully listening. Freaky stuff.
poster:Ritch
thread:234222
URL: http://www.dr-bob.org/babble/20030614/msgs/234531.html