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Re: Provigil Q. Dark Lord Mitch et al

Posted by avid abulia on June 13, 2003, at 23:44:38

In reply to Provigil Q. Dark Lord Mitch et al, posted by Geezer on June 13, 2003, at 22:19:05

no, what it means is that modafinil does not work on the dopaminergic system to provide it`s wakefulness promoting effects, i.e. you can still have it work for you even if you are taking an antipsychotic.

you might try that slow titration, it may work... but it is postulated that modafinil has its effects primarily through indirectly increasing glutamate and decreasing gaba release, and if klonopin helps correct your problem with it then it probably is not the right drug for you. depression is frequently linked to low levels of gaba, and nmda-type glutamate receptor antagonists or partial agonists (i.e. sort of like a dimmer switch rather than just turning the light out completely) have recently gotten some attention as putative antidepressants--nomifenisine is one such drug, i believe.

~AA


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poster:avid abulia thread:233841
URL: http://www.dr-bob.org/babble/20030609/msgs/233866.html