Posted by jrbecker on May 10, 2003, at 10:48:27
In reply to Re: Please, need info from Prozac users/former users! » Ame Sans Vie, posted by Edgefield on May 9, 2003, at 14:10:43
Prozac is by far my favorite of the SSRIs. I am quite sensitive to most ADs, so my optimum dosage was probably 10mg. At this level, the sedation was minimal.
In my opinion, the "feeling" you get from Prozac is much less numbing than you get from the other SSRIs. It acts on GABA too, so perhaps this is why it's great for anxiety for some people -- I really never found prozac all that activating since I took it at such low doses.
ANnother thing to note about prozac is that it is an antagonist at the 5HT2C site, which is quite the opposite effect from all the other SSRIs. As a result, there is an increase in dopaminergic/NE activity in the prefrontal cortex. It's my belief that this is the reason prozac is a better drug for treating anhedonia than the rest of the SSRIs.
http://biopsychiatry.com/fluox5ht2c.htm
The two biggest complaints from taking prozac were sleep disrution (usually only at higher doses) and sexual dysfunction. Both of these are probably exacerbated by its long half-life. In the end, they seemed worth the sacrifice considering the other options in the class.
poster:jrbecker
thread:225329
URL: http://www.dr-bob.org/babble/20030505/msgs/225563.html