Posted by Caleb462 on May 2, 2003, at 2:31:49
In reply to Can Anybody help answer this question?, posted by McPac on May 1, 2003, at 18:47:04
> These are characteristics of Remeron:
> NE-alpha2 antagonist
> 5-HT2a antagonist
> 5-HT2c antagonist
> 5-HT3 antagonist
> H1 antagonist
>
> Zoloft:
> 5-HT reuptake inhibitor
>
> Now the question....if someone were to take Remeron AND Zoloft together.......if Remeron is an ANTAGONIST of different 5-HT receptors and Zoloft is a 5-HT inhibitor, would the two meds be CANCELLING each other out at these sites (thereby producing little good effects)? THANKS!
Well... Antagonism of 5-HT2 receptors could be a good thing when combined with Zoloft - no ihibition of dopamine. Aren't the 5-HT1 receptors considered the most important in terms of anti-depressant response? I'm not sure... I'll do some searching and get back to you if I find anything good.
poster:Caleb462
thread:223705
URL: http://www.dr-bob.org/babble/20030429/msgs/223787.html