Sam-e; causes 5-HT, NE, DA depletion?

Posted by rod on April 28, 2003, at 5:47:20

So what now? I was thinking it enhanches and raises dopamine, increases 5-HT etc. and is a "miracle drug" for some endogenous depressed.
But have a look at:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8748929&dopt=Abstract
"Striatal dopamine depletion, tremors, and hypokinesia following the intracranial injection of S-adenosylmethionine: a possible role of hypermethylation in parkinsonism."
...Increased methylation can deplete DA, NE, and 5-HT;..

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8503824&dopt=Abstract
"S-adenosyl-L-methionine decreases motor activity in the rat: similarity to Parkinson's disease-like symptoms."
.. Its biochemical role, which includes the metabolism of dopamine and the synthesis of acetylcholine, also resembles the changes that occur in Parkinson's disease...

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1359575&dopt=Abstract
"Parkinson's disease-like effects of S-adenosyl-L-methionine: effects of L-dopa."
..Biochemically, increased methylation can cause the depletion of DA, NE, 5-HT...

Is this really well known, and just I didnt know of this? Isnt Sam-e known to induce mania? but how? Did I miss something? I dont understand this!
I dont know any further
bye
Roland

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Sam-e; causes 5-HT, NE, DA depletion? rod 4/28/03
PS: Sam-e; causes 5-HT, NE, DA depletion? rod 4/28/03
Re: PS: Sam-e; causes 5-HT, NE, DA depletion? Bill L 4/28/03
Re: Sam-e; causes 5-HT, NE, DA depletion? Larry Hoover 4/28/03
Re: Sam-e; causes 5-HT, NE, DA depletion? rod 4/28/03
Re: PS: Sam-e; causes 5-HT, NE, DA depletion? stjames 4/28/03
Re: PS: Sam-e; causes 5-HT, NE, DA depletion? jemma 4/29/03
Re: Sam-e; causes 5-HT, NE, DA depletion? rod 4/29/03

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