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Re: Abilify and akathisia

Posted by JohnX2 on January 26, 2003, at 0:53:03

In reply to Re: Abilify and akathisia, posted by River1924 on January 25, 2003, at 21:18:18


Does the potential for akathisia get worse over
15 mg/d?

I have been taking this medicine just short of 2 weeks 20 mg/d. The medicine takes 2 weeks to build up in your system.

I get this funny response where I feel akathisia for about 4 hours after a dosing and then it goes away. I seems odd to me because the medicine has such a long 1/2 life (like 90 hrs)?

J

> Found this on the web...
>
> "Potential Problem with Akathisia
> According to Larry Ereshefsky, Pharm.D., professor of pharmacy, pharmacology and psychiatry at the University of Texas Health Science Center at San Antonio, the novel partial dopamine agonist mechanism of action augments the 5-HT1a and 5-HT2 effects of aripiprazole.
>
> "These effects should lead to greater dopaminergic throughput and cortical activity which is good for thinking," says Ereshefsky. "But it also might possibly explain the increased rates of akathisia at [the] middle doses (15 mg/d) in some studies. There is clearly a greater effect on the Barnes akathisia scale than [from] risperidone, and about half the effect of haloperidol."
>
> Ereshefsy adds, "Akathisia is a potential side effect which bares further evaluation in long-term studies to see whether it abates."


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poster:JohnX2 thread:129761
URL: http://www.dr-bob.org/babble/20030125/msgs/137578.html