Posted by ItsHowdyDudyTime on November 28, 2002, at 23:08:42
In reply to Re: Update on hard to treat depression strategies, posted by SLS on November 28, 2002, at 20:54:39
> Zyprexa (olanzapine) is becoming increasingly recognized as being a potent adjunct for bipolar depression and other treatment-resistant depressions (TRD). I am currently experiencing encouraging results with the following combination:
>
> Lamictal 300mg
> Nardil 90mg
> Zyprexa 5.0mg
>
> Zyprexa has been combined successfully with the SSRIs. In fact, Eli Lilly, the manufacturer of both Prozac and Zyprexa, has combined these drugs into a single preparation and will likely be approved for the indication of bipolar depression and perhaps later for TRD and psychotic depression.
>
>
> - ScottScott, zyprexa can be used for type one bipolar without too many troubles. However for unipolar major depression that is TRD, Zyprexa is not a wise choice. Those afflicted with unipolar major depression tend to not have the higher dopamine levels that schizophrenics and classic type one manic depressives have. Thus we cant tolerate even low dose atypical anti-psychotics very well, much less for long time periods.
Better solutions are needed. Drugs which dont cause dopamine blockade and have acceptable side effect profiles. At the moment of this writing, there are really only two effective treatments for unipolar TRD and those are ECT and MAOIs.
Have you ever considered ECT, Scott?
Howdy Doody
poster:ItsHowdyDudyTime
thread:129604
URL: http://www.dr-bob.org/babble/20021127/msgs/129830.html