Posted by turalizz on November 25, 2002, at 3:28:51
In reply to CRH and atypical depression, posted by jrbecker on November 24, 2002, at 18:39:50
I have atypical depression, and my cortisol as well as ACTH levels are very high (36.1 mcg/dl for CRT, 34.1 pg/ml for ACTH in the morning)
What would be the benefit of increasing my cortisol even higher with CRH agonist?
In the past, I responded well to remeron, which is a cortisol blocker.
cem
> Would CRH agonists (in conjunciton with an AD)work for atypical depressives just as melancholic types might one day benefit from CRH antagonists?
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> Supposedly the difference between atypical depressives and melancholics is that in atypical depressives, the overproduction of cortisol has finally desensitized the cortisol receptors, making them less responsive. Simulataneously, the high levels of cortisol has a negative feedback effect on the production of Corticotropin-releasing hormone, creating a rapid rise and fall effect in stressful situations. In melancholics, chronic over-stimulation of cortisol has not fully desensitized the cortisol receptors, so stress remains high at all times.
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> Hopefully CRH agonists are being studied for atypical depression just as CRH antagonists currently are for melancholic types.
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poster:turalizz
thread:129105
URL: http://www.dr-bob.org/babble/20021122/msgs/129167.html