Posted by BrittPark on November 5, 2002, at 11:54:39
In reply to More about VICODIN, please! » Jerrympls, posted by vincent on November 5, 2002, at 11:23:14
There is a company called Pain Therapeutic developing less tolerance producing formulations of morphine and oxycodone. Their formulations are based on the observations of Crain and Shen, who noted that a combination of an opiate agonist, like morphine, in combination with a small amount of an opiate antagonist, like naltrexone, increases the analgesic affect of the opiate, and stops tolerance development in rats. They are in Stage II trials (safety).
If these formulations make it to the market they may be magic bullets for TRD. Of course they may not. Perhaps the addition of naltrexone eliminates the euphoric effect, or has no effect on tolerance to the euphoric effect. In which case they are unlikely to be of use in the treatment of depression. This is assuming that the AD effect of opioids is identical to the euphoric effect of opioids.
poster:BrittPark
thread:126471
URL: http://www.dr-bob.org/babble/20021101/msgs/126515.html