Posted by action_jackson on August 31, 2002, at 2:55:10
In reply to Re: Did your Dr. warn you of Tardive Movement Disorder, posted by cybercafe on August 30, 2002, at 12:36:27
Ross -
Studies so far with these new atypicals - the large studies - are primarily done on schitzophrenics and bipolar's in "manic" state - or perhaps in "psychosis". All of these groups are most resilient to getting tardive EPS or tardive movement disorders. Affective patients (those getting atypicals at low dose for "off-label" use) - are the ones at much higher risk - and large studies are few to none in this area ...
There are numerous case reports of low dose risperidone and other atypical a/ps inducing tardive dystonia, chorea, TD, etc... and mostly these are "case reports" so far - and I see usually the abstract text is usually "blocked" in these particular cases on Pubmed. You can see on this board alone that many here have tardive eps and have no condition consistent with accepted use of atypicals ...
anyway... a couple abstracts - also keep in mind as I said I believe this stuff is way underreported - people here for example are mentioning peramanet drug senstitivity or eps and saying things like "oh by the way I was also taking low dose risperidone..." ...
I think it will take awhile - the Dr's are not telling the patients that their eps was caused by the Dr's drug - virtually no Dr. wants to do that because using these drugs off label and causing that stuff is negligent.
So these simple case reports - none of them is going to seem convincing to your question - I can't give you hard proof ... if I could afterall - there wouldn't really even be a debate on this topic ... I think time will tell...
Still - after copying some of these - I got tired - a lot even though I'm sure is just a tiny percent of cases as most are unreported in jounrals or maybe even understood by patients as what really caused their problem.
Also keep in mind that A/P's "mask" tardive movements - so often a person will take an A/P - get a disorder - and never know until discontinuing - then will have to back on the A/P just to prevent the new movement disorder caused by brain lesion - which is likely going to continue to get worse as they age and continue on with A/P's.... A damaged brain is not usually repairable ...
Chad
http://www.socialfear.com/
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9752071&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8990067&dopt=Abstract
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8899136&dopt=Abstract
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9727307&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9562211&dopt=Abstract
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9949942&dopt=Abstract
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9491064&dopt=Abstract
> > Your Dr. gives you an antipsychotic? And he does that in combo with a dopamine agonist (Nardil) - which increases risk of tardive movements. (so would wellbutrin + a/p, etc...)
>
> where did you hear this?
>
poster:action_jackson
thread:118184
URL: http://www.dr-bob.org/babble/20020829/msgs/118320.html