Posted by Shawn. T. on July 26, 2002, at 3:17:56
In reply to Re: downregulation??, posted by cybercafe on July 26, 2002, at 0:53:18
> okay i'm really sleepy so i'm going to have to fly through this
>
> > I believe it is a combination of two molecules which can fit another molecule into it.
>
> hmmm... okay, may i ask where you arrived at that conclusion from
>
I suppose that I jumped at that conclusion. The definition of dimer is "A molecule which consists of two similar (but not necessarily identical) subunits."
Here's an image of what I was imagining:
http://hsc.virginia.edu/medicine/basic-sci/pharm/garrisonresimage.gif
and
http://www.nature.com/nrn/journal/v2/n4/slideshow/nrn0401_274a_F3.html
http://home.uchicago.edu/~yuanzhou/note2.htm
> >functional coupling to an inward rectifying K+ channel. Rectifying would seem to be used in the electrical context here, so I believe it means to convert alternating current into direct current.
>
> rectifying means current is only allowed in one direction... inward rectifying means, K+ ions are only allowed to travel inward ... probably due to some active transport mechanism (as diffusion would cause it to flow outward)
correct> ... there are some excellent discussions on this and much more in Kaplan and Sadock's Comprehensive Textbook of Psychiatry (Not Synopsis of Psychiatry)
>> > There was a thread earlier about GHB; I'll try to apply what I've said to it. There have been arguments made that GHB may actually be a
>
> if i could actually get my hands on GHB, i do have some guinea pigs awaiting
>I wouldn't doubt that.
> >pain regulation. For instance, 5-HT3 may be negatively coupled with GABAb. GABAb may be able to inhibit substance P release. So when 5-HT3 is activated, substance P is released. A 5-HT3 antagonist like Remeron should therefore inhibit substance P release, which it has been shown to
>
> it probably depends on what brain circuit you are talking about...
>
true. I'm thinking about the autonomic nervous system, so perhaps this would take place in the hypothalamus (a guess; I'll try to find out more about this later). It would definitely have to be a region that has access to descending inhibitory pathways (e.g. the spinal cord).> for example, i have been concerned with the nucleus accumbens, and i know that 5HT3 has positive effects on the release of dopamine, and substance P may have negative effects....
I immediately thought schizophrenia when I read that. I think that Remeron might be a great choice for the treatment of schizophrenia.
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=23334753
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=22939439
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=20603959The 5-HT3 <-> dopamine connection really has me interested now. I'll throw some more links at you later.
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=25665543
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=25337852
therefore i wonder if a 5HT3 agonist may display substance P antagonism .... but that would be a jump in logic.. and i see no reason to make jumps in logic when there is solid information out there ... or at least until i have run out of solid information to go on :)
>
> cybercafeI don't always trust the solid information out there; I usually try to look at things from several different angles before coming to a conclusion (actually I consider everything that I know to be tentative; if I didn't, I wouldn't be very interested in learning more). I don't have time to read absolutely everything, so I often use logic to fill in smaller gaps in the information that I come across. I'm an INTP by the way; perhaps I use logic too much, but it doesn't fail me as often as taking some information at face value does. I have been taught to be ever critical of everything that I read; everyone is prone to make mistakes, myself included. The solid information out there seems to indicate that a 5-HT3 agonist would induce the release of substance P.
http://www.cfs.inform.dk/Tropisetron/iv.tropisetron01.txt
Shawn
poster:Shawn. T.
thread:113408
URL: http://www.dr-bob.org/babble/20020725/msgs/113774.html