Posted by Shawn. T. on July 19, 2002, at 15:45:29
In reply to general info on inositol, posted by katekite on July 19, 2002, at 9:57:18
Thanks Kate. I was lying in bed last night and realized that I shouldn't have been calling it a vitamin. That page helps out my attack on caffeine. They've been trying to ban it for years in some Muslim countries; now I really see why from many different angles.
"Caffeine in large quantities may create an inositol shortage."
1 From Griffith HW, Vitamins, Minerals, and Supplements.Note that I should have said that people with depression have too many 5-HT2a and 5-HT2c receptors. Without any treatment, those receptors would usually be hyposensitive. I would say that 5-HT1a receptors are probably hyposensitive in depressed people as well. In a person with bipolar disorder, they would have too few 5-HT2a and 5-HT2c receptors (too few 5-HT1a receptors as well?). So those receptors would be hypersensitive in a manic state and hyposensitive (because of the brain's neuromodulatory feedback mechanisms) in a depressed state. I am beginning to realize that I probably actually do have a form of Bipolar II disorder. I get depressed in the fall and winter, and I usually feel much better in the spring and summer. I now realize why Remeron has helped me so much. I think that a 5-HT2a/5-HT2c antagonist is probably a good idea for bipolars. I've read that Wellbutrin can help and doesn't cause cycling as well. So Remeron plus Wellbutrin works well for me. I don't know what to make of that. I would guess that my receptor numbers are not too off kilter, but they are just enough to cause a problem when I'm not taking drugs to treat it.
Depressives probably have hyposensitive 5-HT1a,
5-HT2a, and 5-HT2c receptors. I'm not so sure anymore that we should even mess with 5-HT2a and 5-HT2c receptors at all when treating depression. Flooding the serotonergic synapses of a depressed person with serotonin will serve to initially create a situation in which 5-HT1a, 5-HT2a, and 5-HT2c receptors will be activated way too much. This will result in a large increase in anxiety. SSRI's are just too nonselective. Maybe a selective
5-HT1a agonist like gepirone would be best. Drugs acting at inisotol receptors would be very interesting.Shawn
poster:Shawn. T.
thread:112842
URL: http://www.dr-bob.org/babble/20020718/msgs/112918.html