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Re: ATTN: Shawn T.

Posted by Shawn. T. on July 16, 2002, at 15:50:25

In reply to ATTN: Shawn T., posted by cybercafe on July 16, 2002, at 15:22:39

I believe that the anti-psychotic effects can be mostly attributed to dual 5-HT2a/5-HT2c antagonism. Ritanserin does not seem to bind to 5-HT2c receptors; that has important implications for its use as an anti-psychotic (e.g. it's not effective as often as we would like). Mianserin
should be a potent anti-psychotic because it effects both. Nefazadone blocks these receptors also, but not as potently as Mirtazapine or Mianserin. I like the last two drugs mentioned because they lack extrapyramidal side effects. They don't bind as well as some of the newer atypical anti-psychotics like Olanzapine to 5-HT2a receptors, but I bet they're just about as effective with fewer side effects. Note that I do not believe 5-HT2b is implicated is schizophrenia.

I get all my binding data from
http://www.gpcr.org/7tm/ligand/Organon/ORG_ligand_ALL.html
--I really love that site.

Check out the following link for information on Mianserin for schizophrenia:
http://www4.infotrieve.com/search/databases/Results.asp?SR=1&QR=mianserin+and+schizophrenia&FY=1973&TY=2002&NR=10

A similar search for Nefazadone and schizophrenia found no results.


Shawn

>
> i remember you writing that Remeron was shown to work as an anti-psychotic... was that due to 5HT2A antagonism alone, or through antagonism of all 5HT2 receptors?
>
> ... and have similiar results been shown with all 5HT2A antagonists (Serzone/Nefazodone, Ritanserin,mianersin, etc)?? have the results been bad, or have there just not been any?


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