Posted by JohnX2 on June 9, 2002, at 1:18:44
In reply to Re: MAJOR Benzo responder...what best A.D's? » JohnX2, posted by jay on June 9, 2002, at 1:02:03
> >
> > I'm personally interested in this novel AED Keppra.
> > Dr. Goldberg was talking about some positive experience
> > for treatment resistant bipolar.
> >
> > There were some abstracts showing in animal models
> > that it negated the crummy effects of a BZD antagonist (a medicine
> > that blocks the benzo site).
> >
> > But its pretty new...
> >
> > John
>
> Hmm..interested...but if this turns out to be another 'Neurontin'..well..ughh. (Anti-Neurontin rant..:-)..That med acts *nothing* like benzos, from my experience, and I really see little evidence for it in treating anxiety, GAD, PAD, etc. As for it as an 'anti-depressant'...bahhh..what a stretch!
>
> I do have one interesting experience with Buspar. I was thinking of maybe taking it again. I took a good dose of Buspar (I think I took 15-20 mg's 2x a day), and a good benzo dose, and man I got a very excellent response. Maybe it's all the mucking around with a mix of dopamine, serotonin agonism/antagonism and the benzos.
>
> If this works...I will post indeed!
>
> Thanks...
> JayYeah, I thought the Keppra looked interesting because I
grew tolerant to Klonopin which has been my best stabilizer to
date. Neurontin was a bit of an anxiolitic, but nothing like
the benzos as you mentioned.In those animal studies of Keppra, they were able to give the
animals anxiogenic medicines that blocked the Gaba benzo receptors and
this did not induce seizure activity. I don't know if there is
any other AED that can claim to do that. But this is in animals
and its early in the game so who knows (need some real world data).It's interesting you did well with Buspar. Some people believe
that hyperactive sertonergic action is the culprit behind anxiety.
Both buspar and the benzos (GabaA agonists) reduce the firing rate
of hyperactive serotonin neurons.John
poster:JohnX2
thread:109142
URL: http://www.dr-bob.org/babble/20020602/msgs/109228.html