Posted by Chloe on June 7, 2002, at 21:32:07
In reply to Re: Trimipramine » Chloe, posted by Ritch on June 6, 2002, at 23:18:29
> Chloe,
>
> I went to www.mentalhealth.com and went into their research topics (Medline) through the drug monograph. It seems like it was used (as doxepin was) to treat ulcers back in the '70's and '80's before the modern H2 antagonists were available. What it appears to me after reading a lot of the stuff about it is that it may not be as potent an antidepresant as other TCA's are, but doesn't hose up sleep architecture like other TCA's can and still has some antidepressant effect and helps sleep. One study I checked into showed that it tends to reduce cortisol similar to AP's, without other major changes in other hormone levels (that caught my attention). So, perhaps you might not get as irritable as on amitrip.? However, you are partly using the amitrip. for neuropathic pain, and I didn't see any studies on neuropathic pain. Oh, well.
>
> MitchMitch,
I like the part about it being a dopamine antagonist without it being a true AP. My pdoc emailed me tonight, and thought trimipramine was a great idea especially because of this property. She called in the script, ASAP. I was shocked she moved that fast on a friday night, hum...
BTW, Trimipramine, for me, is NOT generic. It cost $21 for sixty caps! I was shocked. My ami is $7 no matter the quantity. Strange that a TCA is not generic. I thought all these meds were from the stone age, and long lost their patents. The pharmacist couldn't tell me why it was so pricy either. Hope it works!I was looking through SLS's extensive list of meds and their properties and I can outline the difference between ami and trimipi, if you are interested...
TRIMIPRAMINE:
dibenzazepine
tertiary TCA
DA2 antagonist
Ca2+channel inhibition
ACh(m) antagonist---not sure what this one is??
NE-Alpha1 antagonist
H1 antagonistAMITRIPTYLINE:
dibenzocycloheptadiene
tertiary TCA
NE reuptake inhibition***
5-HTP reuptake inhibition
5 HT2 antagonist
ACh antagonist
NE-alpha1 antagonist
H1 antagonist***I wonder if it's the NE reuptake inhibition that makes me get so grouchy and short fused?
Anyway, that is the difference between the two according to SLS (thanks, SLS!). Do you have any thoughts on this, Mitch?
Oh, lastly, I did read on the medline drug list, that an unlabeled use of trimip is *neurogenic* pain. So I am hoping I will continue to have some relief in that area. Phew, my agitated depression has swung into frenzied energy and giddiness. It's so hard to sit and focus! Can you tell?
Catch ya later, oh and how are you??
Chloe
poster:Chloe
thread:108844
URL: http://www.dr-bob.org/babble/20020602/msgs/109121.html