Posted by Leighwit on June 3, 2002, at 11:59:20
In reply to Re: Despiramine » geno, posted by JohnX2 on June 1, 2002, at 23:42:47
John,
Have you taken desipramine? I haven't read many of your posts; maybe you're extremely knowledgeable about these medications in general (great post to geno.)
If you have taken it, I wondered if you knew of any differences between Norpramin and Desiprimine.
Thanks so much,
Laurie> > Desipramine has been mind boggling for me. My pdoc says its good for sleep and anxiety, but it seems to boost more norepinephrine. Im not panicy on it, but i feel a tingly sensatioin through my head and raised heart rate. No social phobia benifits. I think adderal/ritalin or dexadrine are better for social states than desipramine. I dont like my heart racing, esp when working out.
> >
> > I dropped desip, and took some ritalin, which mad me feel a bit better, along with zoloft and klonopin. But i still dont have my zoloft to 100mg yet. Im still not out going social finatic as i wanna be.
> > geno
>
>
> Are you taking this Desipramine with Remeron?
>
> The Desipramine is a norepinephrine reuptake inhibitor.
> In a key stress area of the brain called the locus coeruleus,
> the firing rate of neurons is somewhat directly related to
> stress/heart rate etc. Usually over time NRI's in this area
> will increase norepinephrine in the synapse but slow down the
> firing rate by desensitizing norepinephrine alpha-2 feedback receptors.
> This helps with depression and anxiety.
>
> Now Remeron blocks those alpha-2 feedback receptors, causing
> an increase in norepinephrine release and firing rate on top
> of the Desipramine reuptake inhibition maybe negating the
> whole gig. Just a hypothesis on my behalf.
>
> Pure blockade of alpha-2 norepinephrine receptors themselves have
> been shown to induce panic attacks (like taking yohimbine
> for some people). Remerons anxiolytic serotonergic action
> helps to negate this. (I believe this is the case don't quote
> me).
>
> John
poster:Leighwit
thread:107878
URL: http://www.dr-bob.org/babble/20020602/msgs/108533.html