Posted by Ritch on May 17, 2002, at 1:01:03
In reply to JohnX2 and Ritch - question for you both, posted by rainbowlight on May 16, 2002, at 15:17:46
> Okay, I am lowering the Zoloft per doctors orders. I have a few questions for you. When a med works well for the first month, and then it makes you physically sick is it possible that the dose is just too high and that lowering it may help? Also, if I am having a drug interaction, if I got off my other meds would Zoloft give me the same good benefits I was having or is the good effect only because I am on a combo of meds? Hope this makes sense! Thanks
Hi,I think it is just the dose of the Zoloft. You were taking xyz medications and then you added Zoloft at a certain dose. You felt a *lot* better-so the Zoloft is helping *something* at *some* dose.. But, over *time* things got a little unstable and weird. Well, Zoloft has a half-life of 24 hrs, but it has a pharmacologically active metabolite that has a half-life of 2-3 *days*. Given that, it would probably take the Zoloft dose/day you were taking to slowly climb to a steady level after a couple of weeks at least. Also, if other meds you were taking were indirectly blocking the elimination of the Zoloft, then it would take *even longer* to slowly reach a steady state level of Zoloft+primary metabolite. Probably about the time you started getting "your toes in your nose". Sounds like a drastic Zoloft dose reduction would be a wise thing to get you back to feeling better without feeling wacky. Just a guess. Hey, if it helps any: I was taking just 6.75mg of Zoloft every three *days* at one time!
Mitch
poster:Ritch
thread:106689
URL: http://www.dr-bob.org/babble/20020510/msgs/106742.html