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Re: Neurotransmitter/Receptor Tables

Posted by Jodeye on May 7, 2002, at 12:43:31

In reply to Neurotransmitter/Receptor Tables, posted by tinker on May 7, 2002, at 6:38:54

> Looking further at the spread sheet called Effects of Antidepressants on Neurotransmitters/Receptors: the following is at the bottom of the sheet. "The ratio of Ki(nM)>100,000= then it gives values, and a second set of values is included after 1/Ki(M),0.001. My question is how do you know which set of values applies. Zoloft (Sertraline) has ++ beside NE reuptake, this could mean 10-1000 under the first set or 0.1-1 under the second set. Under 5 HT Reuptake it has ++++ which could mean 1-10 or 10-100. I am trying to find out the difference between clomapramine and zoloft. The pharmacist gave me this table. But I'm not sure how to apply the numbers. Any insights would be much appreciated.

Hi,

I am not sure what your numbers mean, but I beleive that a phrase such as "Substance X has a Ki50 of 10,000 nM" would mean that 10,000 nM of Substance X in your blood would effectively bind to 50% of the receptors in question.

nM = nano mole. (a quantity of molecules).
Ki = Inhibition constant.
Ki50 = 50% of the receptors in question have been bound to.

Hope this helps, because it's not really clear to me either.

--Jodeye


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