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Re: 'Sulpiride' and anxiety

Posted by JahL on May 4, 2002, at 9:08:02

In reply to Re: 'Sulpiride' and anxiety, posted by tex1 on May 4, 2002, at 7:12:30


> The anti-anxiety effects does exist, but not at the dosage reccomended for depression (as here in Europe is prescriped mostly for this). The amisulpride dosage is usually 50 mg day in this case.

We'll have to agree to disagree :). I suggest maybe going back through the archives and reading some of AndrewB (a v. well respected & knowledgable 'old timer')'s posts. He achieved a "pure anxiety effect" for social phobia at precisely the Amisulpride dose you mention, possibly less. We've emailed one another once or twice in the past & the guy definitely knows what he's talking about.

>Over this dosage you're surely going to feel an anti anxiety effect due to the dopaminergic receptors blockage. So it mostly looks like an "anergic" and "ataraxia" effect than a pure anti-anxiety effect.

The idea that APs only relieve anxiety through sedation (I assume this is what you mean by 'anergic effect', though I could be wrong) is an old one and is not entirely true. Besides, the higher my Sulpiride dosage goes over 200mg, the LESS effective it becomes for anxiety.

Even at tiny doses of Sulpiride (ie a quarter of the smallest tablet available) I experience a clear "pure anti-anxiety effect", ie a meaningful reduction in the frequency and intensity of anxious thoughts. Of course my experience isn't necessarily typical but I am proof positive that at low doses, Sulpiride can be, *for some people*, a 'pure' anxiolytic. I do not experience sedation, or any other side-effect w/ Sulpiride.

I'm not sure you can predict the response an individual will experience with a given drug just by analysing its pharmacological profile. Would you believe, for example, that I also take low-dose Methadone for *energy* and *mental clarity*, both of which are adversely affected by opioids, according to conventional wisdom?

Ataraxia means 'peace of mind'. Isn't that analogous to 'reduction of anxious thoughts'?

Anyway, that's me done.

Best regards,
J.


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