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Re: Wellbutrin and Dopamine

Posted by mat on April 26, 2002, at 11:48:24

In reply to Wellbutrin and Dopamine » mat, posted by DP on April 26, 2002, at 9:59:48

> I heard that Wellbutrin doesn't have much effect on Dopamine at such low doses as what I'm taking (150mg qd).

hi!
from stephen m. stahls "essential psychopharmacology":
bupropion itself seems to have rather week dopamine reuptake-inhibiting properties, and weaker yet noradrenaline reuptake-inhibiting effects. bupropion is more of a "pro-drug" than a drug itself: it is metabolized to several (three?) different compounds, one of which (hydroxybupropion) seems to be the active metabolite, that is responsible for the antidepressant effects of bupropion.
i know that this doesn't answer your question exactly, but i can't find out more at the moment!
mat


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poster:mat thread:104150
URL: http://www.dr-bob.org/babble/20020425/msgs/104205.html