Posted by turalizz on April 17, 2002, at 9:49:13
In reply to SNRIs: Desipramine vs. Reboxetine » geno, posted by fachad on April 16, 2002, at 16:19:19
> Both desipramine and reboxetine are SNRIs.
>
> Desipramine is far more potent at blocking NE reuptake than Reboxetine. The 1/K values are 120 for desipramine and only 14 for reboxetine. So desipramine is more than 8 times more potent than reboxetine. For comparison Elavil is 3, Paxil is 2.5, and Prozac is 0.5.
>
> Reboxetine is also less selective than desipramine. The ratio of selectivity NE:5-HT is 21 for desipramine, and it is 8 for reboxetine.
>
> I don't really know what all the hype is about reboxetine, because it is less potent and less selective than desipramine. It is, however, more profitable because it is still under patient. That probably explains the hype.
>
Fachad, did you personally compare desipramine to reboxetine yourself? Or are you just talking about the "theoretical" stuff you read from some book?cem
poster:turalizz
thread:103083
URL: http://www.dr-bob.org/babble/20020416/msgs/103325.html