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Re: New Meds for anxiety/depression??

Posted by paulb on April 11, 2002, at 18:11:33

In reply to New Meds for anxiety/depression??, posted by Mason on April 10, 2002, at 17:46:44

There are a lot of new meds in the pipeline. the best ones i can think of are mixed agonists/antagonists in the same class of mechanism as nefazadone but also drugs which share a combination of nefazadones antagonism and rather than re-uptake of a monoamine mimication of its effect at the receptor in the same way buspirone exerts its effects on GAD. nefazadone which is a newer antidepressant was probably designed for the purpose of eliminating side-effects such as insomnia and sexual disfunction but the problem can be that people can become too sleepy on the nefazadone and that the post-synaptic receptor it blocks is the antidepressant one for some people. i think the newer GABAergic drugs such as pagoclone and pregabalin sound a better bet for GAD. i always thought for generalised anxiety specifically, the benzodiazepines were far superior to the SSRI's.
http://www.nimh.nih.gov
http://www.abpi.org.uk
may be of some use
paulb


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