Re: Aripiprazole and d2 upregulation

Posted by SLS on March 26, 2002, at 19:49:46

In reply to Aripiprazole and d2 upregulation, posted by JohnX2 on March 25, 2002, at 1:55:10

> Aripiprazole, a novel antipsychotic drug, inhibits quinpirole-evoked GTPase activity but does not up-regulate dopamine D2 receptor following repeated treatment in the rat striatum.

Hi John.
This looks encouraging.
Can you find anything that makes a similar comparison to olanzapine or ziprasidone? It might help to elucidate whether or not the reduced magnitude of DA D2 receptor upregulation can be assigned to those properties of aripiprazole that Stephen Stahl characterizes as being of a DSS (dopamine system stabilizer). Aripiprazole has been described by others as being a partial DA receptor agonist.

- Scott

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Aripiprazole and d2 upregulation JohnX2 3/25/02
Re: Aripiprazole and d2 upregulation SLS 3/26/02
Re: Aripiprazole and d2 upregulation » SLS JohnX2 3/26/02

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