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Re: SAM-e » Ritch

Posted by Ron Hill on March 21, 2002, at 4:08:50

In reply to Re: SAM-e Induced Hypomania Colon, Mitch, IsoM et al » Ron Hill, posted by Ritch on March 21, 2002, at 0:17:56

> I have been feeling even better lately.

Mitch, I'm really glad that the SAM-e add-on is working well for you so far. How much are you currently taking? Still 250 mg?

>I am only taking Celexa 2.5mg 3x weekly (my only antidepressant). But, I am taking 2.5mg of Dexedrine every day (afternoons). I really must say-that with the SAM-e addition I almost feel like I could stop the Celexa. I have found more hypomania symptoms with it than I have the dexedrine or the SAM-e, even at its microdose. The thing is whether panic will start returning if I ditch it. Will SAM-e have any sort of antipanic effect that AD's typically provide for folks with PD??

I believe the answer is yes, however, since I do have PD as part of my formal dx, my experience may differ from yours. But for me, I have been pleasantly surprised by what I will call (for lack of a better term) a "soothing, calming, anti-irritability" effect. YMMV.

A couple of days ago, when you were so kind as to send me a list of your current meds, your wrote:

>Depakote 125-250mg hs (no tremor with Flax oil and the SAM-e!)
Klonopin .5mg hs
Neurontin 100mg tid
Dexedrine 5mg/day
Celexa 2.5mg every other day

Your note after the Depakote dose intrigues me. What I read into your statement, and please correct me if I'm wrong, is that at one point in time Depakote caused tremors in you hands. But with the flax seed oil and SAM-e add-ons, the tremors are gone. Do I have it right? If so, my read would be that Depakote can, in some cases like yours, deplete dopamine levels. And, further, SAM-e and/or flax seed oil restore DA levels and/or DA transmission.

-- Ron


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