Posted by Sunnely on March 9, 2002, at 21:45:49
In reply to Does Seroquel Cause Weight Gain?, posted by fachad on March 8, 2002, at 11:21:37
Although weight gain has been reported with quetiapine (Seroquel), it does not appear to be as frequent and significant as that of olanzapine (Zyprexa) and clozapine (Clozaril).
Among the atypical antipsychotics, most notorious for causing weight gain, diabetes, and elevated triglycerides are Zyprexa and Clozaril; ziprasidone (Geodon) the least; risperidone (Risperdal) and quetiapine (Seroquel) in between.
The following is the result of a 10-week, placebo-controlled study, comparing weight change on standard drug doses of antipsychotics (from the most to the least weight gain). Unfortunately, quetiapine not included:
1. clozapine (Clozaril, Leponex)
2. olanzapine (Zyprexa)
3. mesoridazine (Serentil, Lidanar, Lidanil)
4. thioridazine (Mellaril)
5. sertindole (Serlect; Serdolect)
6. chlorpromazine (Thorazine, Largactil, Sonazine, Aminazine)
7. risperidone (Risperdal)
8. haloperidol (Haldol, Serenace)
9. fluphenazine (Prolixin, Permitil, Moditen, Modecate)
10. ziprasidone (Geodon)
11. molindone (Moban, Lidone)
12. placeboSource: Allison et al. American Journal of Psychiatry 1999;156:1686-1696.
> Does Seroquel cause weight gain like other APs?
>
> I know that all the older APs like thorazine caused severe weight gain, and some of the more popular newer ones like Risperdal and Zyprexa are even worse, causing "diabesity" (diabetes and obesity, each feeding the other and making the other worse).
>
> So is Seroquel any different?
>
> I've got tough insomnia, and I've seen quite a few here use Seroquel for that.
poster:Sunnely
thread:97064
URL: http://www.dr-bob.org/babble/20020307/msgs/97267.html