Posted by JohnX2 on February 2, 2002, at 20:36:59
In reply to Re: Only alcohol, benzos, selective for GABA-A??? » 3 Beer Effect, posted by JohnX2 on February 2, 2002, at 20:31:32
whoops, But Topamax is not GabaA selective which is what
you were pointing out with the others.-John
>
> Mr. 3 Beer,
>
> The anti-convulsant Topamax increases Gaba-A conductance.
>
> Btw, what is your favorite beer? ;).
>
> -John
>
> > I was looking at the gabitril.com website and it appears that the proven anxiolytic/social phobia drugs like alcohol, benzodiazepines, & the barbituates only affect GABA-A.
> > http://www.gabitril.com/physicians/gaba/default.asp
> >
> > The Role of GABA in CNS:
> > GABA binds to 3 principal receptors, each of which is involved in different physiologic functions:
> >
> > GABA-A receptors-- mediate fast inhibitory synaptic transmissions; they regulate neuronal excitability (eg, seizure threshold) and rapid changes in mood (eg, anxiety, panic, and response to stress); they are targets of benzodiazepines, barbiturates, and ethanol.
> >
> > GABA-B receptors mediate slow inhibitory potentials; they appear to be important in memory, mood (depression), and pain.
> >
> > GABA-C receptors –– their physiologic role has not yet been described.
> >
> >
> > Since Gabitril is not selective for GABA-A, then would Gabitril cause "dumb drug" effects on memory?
> >
> > Is there a selective GABA-A agonist besides alcohol, benzos, or barbituatues?
> >
> > Also, I can't find the "MAOI of GABA" - Sabril (vigabatrine) in the 2002 Nurses Drug Guide or PDR. Is Sabril available in the United States yet? Is Sabril selective for GABA-A?
poster:JohnX2
thread:92589
URL: http://www.dr-bob.org/babble/20020131/msgs/92663.html