Posted by Raga on January 17, 2002, at 7:38:16
In reply to Re: Psychosis and Modafinil/Adrafinil » Raga, posted by IsoM on January 17, 2002, at 1:22:34
From a monograph on Provigil:
"One healthy male volunteer developed ideas of reference, paranoid delusions, and auditory hallucinations in association with multiple daily 600 mg doses of PROVIGIL and sleep deprivation. There was no evidence of psychosis 36 hours after drug discontinuation. Caution should be exercised when PROVIGIL is given to patients with a history of psychosis."
Multiple 600mg doses sounds plus sleep deprivation sounds like way too much and would probably make practically anyone psychotic!
What it seems to me is that the researchers saw this one case and said "Oh oh, we gotta put in a warning for people with a history of psychosis."
This is unlike Ritalin/Dexedrine, which shows a very significant increase in psychosis on -normal- doses. It isn't just methamphetamine on huge doses, btw. Even though I dislike Breggin, he does go on and on about this point...
I hoping that even though modafinil is a stimulant, it doesn't share this property.The reason I'm asking is that I am ADD but have been avoiding the stimulants for this reason. I have a history of some minor psychosis (which I believe is related to a history of significant psychedelic drug use...) I've had limited success on Wellbutrin, and am about to try desipramine; but then I'm hoping to try modafinil and others and if nothing is really working well enough, I'll give in and take the risk of psychosis and try dexedrine and/or ritalin... That's the source of my question about modafinil...
poster:Raga
thread:90082
URL: http://www.dr-bob.org/babble/20020116/msgs/90584.html