Posted by Mitch on December 1, 2001, at 17:40:44
In reply to tiagabine and vigabatrin, posted by Elizabeth on December 1, 2001, at 15:33:29
> Anyone have any experience with vigabatrin (Sabril) or tiagabine (Gabitril)? Why were you using the drug? What, if anything, did it help with? What side effects were there, if any? Do you have any other information about these drugs and their possible usefulness in the treatment of psych disorders?
>
> TIA.
>
> -elizabethElizabeth, you may have already read my posts about Gabitril. Well anyhow, the behavioural neuro I saw flipped me to Gabitril from Depakote. I started at 4mg at bedtime for one week, then 4mg twice daily for another week, ...adding 4mg per day for a week(slowest titration rate recomended). He was insistent about bringing the dose all the way up to what folks with complex seizures take which is about 32mg/day. The first 4mg at bedtime doses were fairly uneventful. When I went to 4mg twice daily-I noticed an antidepressant effect after taking the daytime dosage. This was true until reached 8mg bid. That is when I started noticing cognitive dulling. But, being very faithful to the trial I continued the slow titration. About two days after I reached 12mg bid I experienced a profound facial/forehead numbness or paresthesia accompanied by derealization. I was so blanked out at work I almost didn't know where I was. I started to "panic", but there was no adrenaline rush-it was like panicking in your head without your body responding. Well, that one got ditched real quick! However, doses between 4-12mg/day did have a distinct antidepressant effect. It might be helpful for a low-dose add-on, who knows??
Mitch
poster:Mitch
thread:85757
URL: http://www.dr-bob.org/babble/20011123/msgs/85765.html