Posted by JohnX2 on November 29, 2001, at 6:34:47
In reply to Re: a2a agonists - CAM,SLS,ETC » JohnX2, posted by Cam W. on November 29, 2001, at 0:34:47
Ooops, sorry if I using a misleading acronym.I was simplifying:
alpha-2 noradrenaline agonist = A2AThere are alpha-2 noradrenaline heteroreceptors
located on acetylcholine cell bodies. An
alpha-2 agonist like Clonidine reduces the firing
of the acetylcholine. Generally the noradrenaline
comes from activation of the locus coerulus.
In a state of nmda hypofunctioning
a pathological activation of acetycholine can
cause neurodegeneration. Another way to treat this
is with a muscarinic3 antagonist, as the
acetylcholine hits this receptor in the
extrapyramidal tract.The simplist adenosine antagonist is our
favorite friend caffeine.regards,
john> John - Aren't A2A receptors adenosine receptors? I know that it is thought that blocking adenosine-A2A receptors is a proposed mechanism of action for Elavil™'s (amitriptyline's) ability to decrease neuropathic pain and for migraine prophyllaxis.
>
> Just a thought - Cam
poster:JohnX2
thread:85388
URL: http://www.dr-bob.org/babble/20011123/msgs/85486.html