Posted by JohnX2 on November 4, 2001, at 23:36:24
Cam et. al,I found this website with information on memantine.
It compares the binding affinities of various
nmda blockers. It acknowledges that the testing
results were only rough guidlines:http://www.pano.com/Products/Memantine/body_memantine.html
Also gives a nice little summary of all the various
little clinical trials.One thing is interesting in Table1.
Of the low affinity inhibitors (the non-competitive
and less toxic ones), dextrophan showed substantially
greater affinity than memantine and then came
dextromethorphan.dizcolipine (Mk-801 worst case) > > > > >
dextrophan > memantine > dextromethorphan.Due you think this makes dxm less toxic
if it's plasma ratio dextromethorphan:dextrophan
was manipulated up. And do you think this would have
a substantial effect on therapeutic results?-john
poster:JohnX2
thread:83228
URL: http://www.dr-bob.org/babble/20011104/msgs/83228.html