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Re: Do Tricyclic side effects wear off? » MB

Posted by Elizabeth on September 12, 2001, at 5:00:24

In reply to Re: Do Tricyclic side effects wear off? » Elizabeth, posted by MB on September 12, 2001, at 1:40:15

> Can you tolorate H-1 blockade pretty well in general?

Yeah, I don't tend to get sedated or dysphoric on antihistamines (Benadryl, Atarax, etc.).

> For me, anything that blocks H-1 knocks me on my butt (and that goes equally for the drugs that "don't cross the blood-brain barrier" like Zyrtec). Is it just your body's response to H-1 blockade? My dad, for example, can take Benadryl and go about his day like it was nothing but a sugar pill. Or, is there something unique about the tricyclics that make you impervious to the sedation?

I think it's at least in part because the TCAs I tried have relatively little histamine-blocking effect.

-elizabeth


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