Posted by grapebubblegum on August 16, 2001, at 8:34:31
This is beyond me, but I cut and pasted this, and I am interested in an interpretation from someone who speaks this language. Most specifically, does this tell you anything about how this medication (Geodon) works for anxiety and/or depression as compared to some of the more traditional medications like the various SSRIs and the benzodiazepines?
"Ziprasidone has a high affinity for dopamine type 2 (D2) receptors and substantially higher affinity for serotonin type 2A (5HT2A) receptors. Ziprasidone also interacts with serotonin 5HT2C, 5HT1D and 5HT1A receptors where its affinities for these sites are equal to or greater than its affinity for the D2 receptor. Ziprasidone has moderate affinity for neuronal serotonin and norepinephrine transporters. Ziprasidone demonstrates moderate affinity for histamine H(1)- and alpha(1)-receptors. Antagonism at these receptors has been associated with somnolence and orthostatic hypotension, respectively. Ziprasidone demonstrates negligible affinity for muscarinic M(1)-receptors. Antagonism at this receptor has been associated with memory impairment."
Thanks, Geeb (who sometimes asks hard questions. ;o)
poster:grapebubblegum
thread:75266
URL: http://www.dr-bob.org/babble/20010814/msgs/75266.html