Posted by adamie on August 10, 2001, at 19:34:04
In reply to Zonisamide for Depression, posted by SalArmy4me on August 10, 2001, at 19:25:18
> I'm starting this drug today. Has anyone tried it?
>
> Department of Neuropsychiatry, School of Medicine, Hirosaki University, Japan. [Effects of carbamazepine and zonisamide on acetylcholine levels in rat striatum]. [Japanese]
> Nihon Shinkei Seishin Yakurigaku Zasshi. 17(1):17-23, 1997 Feb:
>
> "These results indicate that effective doses of CBZ and Zonisamide (ZNS) enhance ACh turnover and extracellular levels of ACh, while toxic doses of CBZ and ZNS (100 mg/kg) decrease them without affecting cholinesterase activity. The effects of CBZ and ZNS on ACh levels may, at least partly, explain the antiepileptic and mood stabilizing effects of these drugs...."
>
> Department of Neuro-psychiatry, Keio University School of Medicine, Tokyo, Japan. The first open study of zonisamide, a novel anticonvulsant, shows efficacy in mania. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 18(4):707-15, 1994 Jul:
>
> "Zonisamide, an anticonvulsant developed in Japan, is structurally similar to serotonin. Zonisamide has been proven to have a pharmacological profile that is very similar to that of carbamazepine. Thus, the effect of zonisamide was examined in 24 psychiatric patients: 15 with bipolar manic state, 6 with schizoaffective manic state, and 3 schizophrenic excitement. 2. Approximately 25% of all the patients and 33% of the bipolar manic patients showed remarkable global improvement with the addition of zonisamide. Approximately 71% of all the patients and 80% of the bipolar group had more than moderate global improvement. 3. No serious adverse reactions were found and no patients required zonisamide withdrawal..."hi. A while ago you mentioned you ordered Reboxetine from Mexico. I was just wondering if you had tried it and if so how it went for you.
poster:adamie
thread:74542
URL: http://www.dr-bob.org/babble/20010809/msgs/74545.html