Posted by Cam W. on August 6, 2001, at 20:53:39
In reply to Rivotril and Klonopin, posted by PaulB on August 6, 2001, at 17:37:37
Paul - There "should" not be any difference between brands, even the generic. The difference can come from the binders and excipients (which are usually cheaper in generic brands), so the tablets may not dissociate (break apart) as easily, and you may lose some in your feces. Also, manufacturers use a range of dosage when making their tablets (95% to 105% of stated dose).
It could be either that your stomach can dissolve the Rivotril™ tablets better than the Klonopin™ tablets. Or the Rivotril lot was closer to the 105% of the dose and the Klonopin was closer to the 95% of the stated dose.
Another thing that I can think of, off of the top of my head, is that the Klonopin could have been closer to the expiry date than the Rivotril, which would make a very slight difference in potency. Or the pharmacy may not have stored the Klonopin properly (could have frozen or overheated) which can affect potency.
There are a lot of little explanations, but the most plausible is that of the tablet dissociation. Testing of tablet breakdown is done, but in different labs, different methods can be used.
I guess, in a nutshell, my answer is the same as everyone else's; I dunno. - Cam
poster:Cam W.
thread:73843
URL: http://www.dr-bob.org/babble/20010804/msgs/73866.html