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HOW DOES FLUANXOL WORK FOR DEPRESSION/ANXIETY?

Posted by SHRINK on June 15, 2001, at 3:18:23

Hi all :-)

I can find a lot of research on the web indicating that Fluanxol (flupenthixol) at low doses (1mg-3mg daily) is as good as most TCA's and SSRI's for the treatment of depression with/without anxiety. Its tolerability also seems better than 'normal' antidepressants (whatever those might be). The one thing that puzzles me is that nobody seems to be offering any information on its *mechanism of action* at these low doses. In higher doses, it's used as an antipsychotic but seems to be antidepressant/anxiolytic at low doses. The same is true for sulpiride (Dogmatil) but - again - no good explanations as to what the drug does differently at low doses to make it a good antidepressant. Does anybody out there able to shed some light on this for me?

Thanks.


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poster:SHRINK thread:66539
URL: http://www.dr-bob.org/babble/20010612/msgs/66539.html