Posted by SLS on June 2, 2001, at 13:12:20
In reply to Re: Lamictal -- PLEASE PLEASE advise » SLS, posted by SalArmy4me on June 2, 2001, at 11:24:30
> > > The chance of having a mild to moderate rash are 3%--according to clinical trials.> > In my opinion, 3% is large enough a number to warrant adherence to the prescribed titration schedule. Line up 33 people. 1 of them might die. Unacceptable.
> >
> > Better to be safe...> The danger of a SEVERE rash leading to hospitalization is 0.03%--three hundredths of a percentage point. Rash is a common problem with many medications, but since Lamictal is newer, patients can't get over the idea that something harmful_could_ occur no-- matter how many hundreths of a percent this "danger" represents.
Whatever, Sal.What percentage of those 3% of subjects you cited who developed mild to moderate rash-reactions were discontinued so that the reaction not reach the point of severity and fatality? Something to think about, eh?
> Did you know that, "At doses of up to 300 mg/day, Wellbutrin's incidence of seizures is approximately 0.1% (1/1000) but increases to approximately 0.4% (4/1000) at the recommended dose (for treatment of depression) of 400 mg/day of the sustained-release formulation or 450 mg/day of the immediate-release formulation."
Yes, I did. I believe I posted such within the last week or so. So, what's your point?
Sal, you can do whatever you want the next time you start taking Lamictal. However, I would suggest to you and anyone else reading this that the potential danger and statistical probability of experiencing a serious rash-reaction using a rapid titration schedule of Lamictal is such as to warrant following the instructions of the manufacturer. What percentage of your patients have you titrated Lamictal rapidly without the appearance of the rash-reaction?
You do a lot of good work here. You wouldn't want to spoil it with an unnecessary tragedy.
> In my opinion, 3% is large enough a number to warrant adherence to the prescribed titration schedule. Line up 33 people. 1 of them might die. Unacceptable.
>
> Better to be safe...
>
> - Scott
- Scott
poster:SLS
thread:64875
URL: http://www.dr-bob.org/babble/20010530/msgs/65174.html